Inspire Hypoglossal Nerve Stimulation

Hypoglossal Nerve Stimulation (HNS) – Inspire®

Inspire®Upper Airway Stimulation is a Federal Drug Administration (FDA) approved treatmentthat includes an implantedsystem, and a patient remote. Inspire is indicated for second-line treatment of moderate to severe Obstructive Sleep Apnea in adult patients with an apnea-hypopnea index (AHI) between 15 and 65. Inspire therapy is not intended for patients with a complete concentric collapse at the level of the soft palate, or those in whom central and mixed apneas make up 25% or more of their apnea-hypopnea index.

The system delivers mild stimulation to the hypoglossal nerve which controls the movement of the tongue and other key airway muscles. By stimulating these muscles, the airway remains open during sleep.Inspire is inserted under the skin in an outpatient procedure that takes two to three hours. Most patients go home the same day.The procedure consists of 2incisions: 1 in the upper right chest where a small device is placed; and 1 just under your chin where the hypoglossal nerveis located.


Inspire therapy has been demonstrated to significantly reduce the severity of obstructive sleep apnea (OSA). Proper treatment may lead to an increase in the ability to perform daily tasks and a decrease in risks associated withuntreated OSA:accidents (e.g., motor vehicle accidents),hypertension, stroke, diabetes, vascular disease, heart failure, and early mortality.

Potential Health Risks

  • Infection
  • Tongue Weakness
  • Swallowing or Speech Related
  • Revision Intervention
  • Discomfort
  • Tongue Abrasion
  • Insomnia/Arousal

Activities to Avoid

Component manipulation: Do not manipulate (move) or rub your stimulator or leads through your skin. This could lead to dislodgement, damage to the components, skin damage or unintended stimulation.

Scuba diving or hyperbaric chambers: Do not dive below 30 meters (100feet) of water or enter hyperbaric chambers above 4.0 atmospheres absolute.

Frequently Asked Questions

How does Inspire therapy work?

Inspire works inside your body with your natural breathing process to treat obstructive sleep apnea. While you sleep, Inspire delivers mild stimulation to key airway muscles, allowing the airway to remain open. The Inspire system is controlled by a small handheld sleep remote. Youturn Inspire on before bed and off in the morning when you wake up.

Is Inspire covered by Insurance?

Inspire is reimbursed by most major insurance providers, either as a covered policy or approved on an individual basis. Your doctor and the insurance team at Inspire will work with you for approval.

What does the stimulation feel like?

You should feel a mild sensation from the stimulationwhen the therapy is turned on. Typically, patients feel a tingling sensation or mild contraction in their tongue muscles. Then stimulation is delayed for a period of time while you fall asleep. After this start delay, stimulation resumes. The stimulation is gentle and designed to move the tongue forward without disturbing your sleep.

Will I be able to increase or decrease the strength of stimulation?

Yes. A range of stimulation will be programmed by your doctor, and the Inspire sleep remote allows you to adjust the strength of stimulation. The stimulation should not be painful or uncomfortable. Stimulation strength can be adjusted so that therapy is comfortable and effective.

How long is the recovery time after surgery?

You should expect some pain and swelling at the incision sites for a few days after the implant. Based on your recovery, you may be able to go home the same day you have the surgery, or your doctor may want to keep you overnight.

Within a few days following the procedure, you should be able to return to normal nonstrenuous activities. You should avoid strenuous activities for about two weeks, or as directed by your doctor. A week after surgery, your doctor will examine you to make sure you are healing properly.

Will the Inspire system limit my activities?

Generally, no. However, you should ask your doctor about any activities that are particularly strenuous (e.g., weightlifting) or that entail a large or unpredictable range of motion of your upper body and/or arms (e.g., working as a firefighter).

Can the device be removed?

It is possible to safely remove Inspire through a surgical procedure when medically necessary. However, this is rare and not recommended in most situations.

Will I need additional sleep studies?

You will need at least one sleep study so your doctor can fine tuneyour therapy settings. Your doctor may need additional sleep studies to monitor and adjust your therapy settings.

Is Inspire DOT approved?

Yourdoctor can print out a usage record of Inspire to show themedical examiner that you are using your prescribed sleep apnea treatment.By provingcompliance, there should be no issues renewing your commercialdriver’s license.

Can I go through airport security with Inspire?

It is safe to go through security screening devices with Inspire.It is possible that Inspire would set off the metal detectorso you should let security personnel know that you have an implanted stimulator and carry your Inspire Identification Card for verification.

How long does the Inspire battery last?

The battery in Inspire is designed to last for approximately 11 years. Once it is running low, it is replaced during a shortoutpatient procedure.

What are the steps after the procedure?

The first 4 to 6 weeks after the procedure the system remains off to allow you to heal. You’ll then have an appointment to have the system programmed with initial settings, receive the remote for your deviceand learn how to use it.

You will then begin using Inspire every night, slowly increasing the amplitude until you reach the point where you are having comfortable restful sleep.

After you’ve gotten used to using the device at home for about12 weeks, you will have an overnight sleep study. At that time,thetechnician will observe your sleeping and fine-tune the device to the best possible way to treat your sleep apnea.

What will the incisions look like after I have healed from the procedure?

The visibility of the scars will depend on your skin tone and individual healing process. You can see examples from these three patients.